Miniaturized lensless microfluidic on-chip bio-imaging detection

Jin CHEN; Xiwei HUANG; Yangbo LI; Jixuan LIU; Lingling SUN

doi:10.11959/j.issn.2096-3750.2019.00111

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Miniaturized lensless microfluidic on-chip bio-imaging detection

Theory and Technology | 更新时间：2024-06-05

- Miniaturized lensless microfluidic on-chip bio-imaging detection
- Chinese Journal on Internet of Things Vol. 3, Issue 2, Pages: 9-19(2019)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.11959/j.issn.2096-3750.2019.00111
  CLC： TP391
- Published：30 June 2019，
  
  Published Online：2019-06，
- 稿件说明：
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JIN CHEN, XIWEI HUANG, YANGBO LI, et al. Miniaturized lensless microfluidic on-chip bio-imaging detection. [J]. Chinese journal on internet of things, 2019, 3(2): 9-19.
DOI：

JIN CHEN, XIWEI HUANG, YANGBO LI, et al. Miniaturized lensless microfluidic on-chip bio-imaging detection. [J]. Chinese journal on internet of things, 2019, 3(2): 9-19. DOI： 10.11959/j.issn.2096-3750.2019.00111.

摘要

用于生物医疗成像的传统高分辨率光学显微镜由于复杂的光学透镜系统导致高成本、不便携。为了实现小型化成像检测，基于CMOS图像传感芯片与微流控集成的无透镜微流控片上成像系统近年来发展迅速，是解决小型化显微成像检测的重要方法。综述了无透镜微流控片上成像系统的结构、成像原理、存在的问题与改进的方法，主要包括阴影成像系统、全息成像系统、荧光成像系统以及彩色成像系统等，分析了无透镜微流控片上成像系统的不足和可能的发展方向。

Abstract

The conventional high-resolution optical microscopy for biomedical imaging has high cost and low portability due to bulky optical lenses system.To realize miniaturized imaging

the recent advance of lensless microfluidic on-chip imaging technique based on the integration of CMOS image sensor and microfluidics has provided one promising solution.Therefore

the architecture

principle

problems and improvement solutions for different miniaturized lensless microfluidic on-chip bio-imaging

including shadow imaging

holographic imaging

fluorescent imaging and color imaging were reviewed.And the deficiencies and possible development directions were discussed.

关键词

片上成像无透镜微流控CMOS图像传感器小型化

Keywords

on-chip imaginglenslessmicrofluidicCMOS image sensorminiaturization

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